Eosinophilic Esophagitis
Eosinophilic Esophagitis (EoE) is a chronic, allergic, inflammatory disorder of the oesophagus. EoE is usually caused by something in the diet, or something that has been inhaled, which triggers an allergic reaction resulting in swelling of the oesophagus. This inflammation usually results in difficulty swallowing. Other symptoms of EoE may include a feeling that food is stuck between the throat and stomach, chest pain, or upper abdominal pain. Additionally, a laboratory test will show a type of white blood cell, called an ‘eosinophil’, to be present in the oesophagus in large numbers, which is not normal.
The study treatment is called CC-93538 (also known as cendakimab). CC-93538 is an antibody, which is made in a laboratory and designed to stop the body’s immune system from triggering the allergic reaction.
The study evaluates the safety and effectiveness of CC-93538 for treatment of EoE and relief of swallowing difficulties.