HyNova - Intraoperative chemotherapy to improve outcomes from ovarian cancer

Heated versus room temperature intra-peritoneal chemotherapy at the time of for stage III ovarian cancer surgical cytoreduction

Ovarian, Fallopian tube and Primary peritoneal Cancers

Recent research suggests that treatment with heated intra-peritoneal chemotherapy at the time of surgery cytoreduction may improve survival in women with ovarian cancer compared to standard intravenous chemotherapy.  This clinical trial evaluates the safety and preliminary efficacy of intra-abdominal treatment with heated chemotherapy, at the time of surgery for ovarian cancer and cancers of the fallopian tubes and peritoneum (the lining of the abdomen).

The primary aim is to evaluate outcomes of using heated intra-peritoneal chemotherapy compared to chemotherapy at room temperature.  The study also evaluates effects of treatment on participants’ quality of life and survival rates.  A third aim of the study is to explore biological markers in the blood which have potential to improve diagnosis and treatment planning for women with ovarian cancer.

Trial Status
Trial Phase
Phase 2 Drug Trial
Trial contact details
Contact Person
Mr Kaltin Ferguson
What you need to know

Who can take part?

  • Women diagnosed with stage III ovarian cancer or cancer of the fallopian tubes or peritoneum who have had a good response to chemotherapy and are suitable for surgery
  • Participants must have adequate liver, kidney and liver function, as determined by a doctor
  • Certain other health conditions and prior cancer treatments may exclude patients from participating, as determined by the study doctor

What is involved for you?

Participants will be randomly assigned to receive treatment with either heated intra-peritoneal chemotherapy or room temperature chemotherapy following cytoreductive.  They will also participate in the following assessments, tests and procedures:

  • Medical history and physical exam, including collection of demographic details
  • Vital signs
  • Review of other medications
  • CT scans
  • Health and wellbeing questionnaires
  • Blood tests
  • Collection of tumour tissue during surgery for laboratory research
  • Collection of blood samples for laboratory research

Trial dates

November 2022 - December 2024

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