Fetal distress in labour
iSEARCH is a multicentre randomised controlled trial aiming to improve outcomes for women and babies. In Australia, almost 1 in 4 caesarean sections are performed for suspected fetal distress, which occurs when the placenta is unable to supply sufficient oxygen and nutrients in labour. The only therapeutic options are emergency caesarean section or instrumental vaginal birth – both of which can have serious consequences. Sildenafil Citrate (SC) dilates blood vessels, thus improving blood flow to baby. iSEARCH evaluates the potential of SC to improve outcomes for women and babies by reducing fetal distress during labour.
A preliminary trial of 300 women at Mater Mothers Hospital published as a Report of Major Impact in the American Journal of Obstetrics and Gynaecology found that taking SC during labour reduced the need for caesarean section or instrumental birth by 50%.