The Sustained Aeration of Infant Lungs (SAIL) Study

Project type/s Clinical trial
Project status Planning/Submitted for approvals

Preterm infants born at extremely low gestational age (between 23-26 weeks’ gestational age) and birthweight (<1000 g) are the most vulnerable and immature in all organ systems, including the lungs and the brain. These infants are at high risk of death and bronchopulmonary dysplasia during their initial hospitalization, neurodevelopmental impairment and pulmonary problems in infancy and childhood.
Sustained Inflation (SI) is a promising delivery room (DR) intervention, with evidence of short-term efficacy with minimal risk of additional harm beyond current standard accepted newborn resuscitation guidelines. We propose to evaluate the impact of a SI in the delivery room on the need for mechanical ventilation in the first week of life which would also impact mortality rates and the incidence and severity of bronchopulmonary dysplasia.

Team Members

  • Haresh Kirpalani - Team Role: Principal Investigator
  • Peter Davis - Team Role: Principal Investigator
  • Prof Helen Liley - Team Role: Principal Investigator
  • Melissa Fernando - Team Role: Project Coordinator
  • Angela Pearson - Team Role: Other (Mater Sponsor / Mater Contact)