Predicting intrapartum fetal compromise at term

Project type/s Clinical trial
Project status Currently underway

Stillbirth or neonatal death of mature infants after the onset of labour in an otherwise healthy pregnancy is one of the top three causes of mortality in singleton term pregnancies and it is associated with intrapartum hypoxia. We have found that combining the fetal cerebro-umbilical ratio (CUR) (measured by ultrasound) as a functional measure of fetal wellbeing, and maternal serum placental growth factor (PlGF) as a biomarker of placental function, at >37 weeks of gestation defines women at greatest risk of fetal compromise in labour. We therefore propose a pilot randomised controlled trial (RCT) to test whether introduction of this test can reduce intrapartum fetal compromise at term.

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