Advanced glycation and pancreatic islets: Using the Network of Pancreatic Organ Donors with diabetes (nPOD) resource

Project type/s Biobank/Databank
Project status Planning/Submitted for approvals

This project aims at investigating the connection between Type 1 Diabetes and dysfunctions of biological pathways involved in the addition of specific sugars to proteins which generate modified variants named "advanced glycation end products" (AGEs). There is some evidence that changes in AGEs and their cellular receptors within the body could alter sugar homeostasis as well as influence the immune system, and ultimately contribute to the onset of diabetes 1. In this project, we hope to gain a better understanding of the relationship between AGEs and their “receptors” at sites that are relevant for the development of type 1 diabetes and if these are unique to this disorder. These studies will help us better understand this system in humans and if it can be targeted by medicines to prevent type 1 diabetes development.

Team Members

  • Prof Josephine Forbes - Team Role: Principal Investigator
  • Danielle Borg - Team Role: Co-Investigator
  • Mark Harris - Team Role: Co-Investigator