frontMIND - A new treatment for newly diagnosed lymphoma


The frontMIND trial is testing a new treatment for patients who have been recently diagnosed with a type of blood cancer called Diffuse Large B-Cell Lymphoma (DLBCL). The study investigates the safety and effectiveness of investigational drug tafasitamab plus lenalidamide. The study aims to determine if addition of the investigational drug to standard therapy for DLBCL improves treatment outcomes for patients compared to standard therapy on its own.

Trial Status
Active, not recruiting
Trial Phase
Phase 3 Drug Trial
Trial contact details
Contact Person
Kim Green - Clinical Research Coordinator
What you need to know

Who can take part?

  • People who have been recently diagnosed and not begun treatment for DLBCL, grade 3b Follicular Lymphoma and certain rare forms of B-cell lymphoma
  • People with no prior history of blood cancers or other cancers, aside from some skin cancers
  • People of reproductive potential must avoid pregnancy during the study

What is involved for you?

Participants will be randomly assigned to receive investigational drug plus standard chemotherapy, by intravenous infusion, or standard chemotherapy alone.  They also undergo the following tests:

  • Physical exams
  • Heart rate & blood pressure
  • Electrocardiogram
  • Blood tests
  • Urine tests
  • Imaging scans:  PET/CT
  • CT or MRI scan
  • Echocardiogram
  • Bone marrow biopsy
  • A tumour biopsy may be required, if samples from a diagnostic biopsy are not available
  • Questionnaires

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