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Home   Researchers   Our researchers
Prof John Hooper

Prof John Hooper

john.hooper@mater.uq.edu.au
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    Prof John Hooper

    • Group Leader - Cancer Biology Research

    Prof John Hooper

    Professor John Hooper is a Mater Foundation Fellow and a Senior Research Fellow at Mater Research. John leads the Cancer Biology Research Group and is the author of over 70 publications with his research currently focused on understanding molecular mechanisms underlying cancer.

    John’s lab has a particular interest in aggressive malignancies, including cancers of the prostate, colon/rectum, pancreas and ovary, and works closely with Mater clinicians to identify key areas of need in these malignancies, with an ongoing emphasis on the role in cancer of cell surface receptor systems. The lab’s work is underpinned by molecular, enzymology and cell biology approaches, analysis of human tissues and pre-clinical models of cancer to identify cancer promoting molecular pathways and to test new anti-cancer drugs.

    Since 2010, John has helped to drive the establishment of gynaecological, urological and breast cancer research teams at the Mater Hospitals. These are closely aligned with Mater’s clinical multidisciplinary teams and involve surgeons, medical oncologists, pathologists, palliative care physicians, nurses and basic researchers.

    John is grateful for the more than $6.5 million in research funding that has supported his research from a range of agencies including the National Health & Medical Research Council (NHMRC), Mater Foundation, the Australian Research Council, Cancer Council Queensland, the Wesley Research Institute and The Prostate Cancer Foundation of Australia.

    'My research focus on cancer continues to be motivated by an innate drive to understand the aberrant molecular interactions that cause cells to grow, move and survive in settings where they would normally die. My goal is to develop novel therapies that modulate these interactions in such a way that they result in cancer cell death, tumour regression and improved patient survival and quality of life.’

    Research Interests

    • Cancer Cell Biology - Oncology and Carcinogenesis
    • Cancer Diagnosis - Oncology and Carcinogenesis

    Current research

    • Group Leader - Cancer Biology Research
    • Program Member - Cancer

    Funding

    • 2016 - Brisbane Diamantina Health Partners (Strategic Initiative Grant Scheme) - $45,000.00
      Funded ProjectThe Queensland Gynaecological Cancer Initiative
    • 2015 - University of Queensland (Queensland Emory Development Alliance (QED)) - $60,420.00
      Funded ProjectTargeting Epigenetic modifying enzymes in aggressive cancers
    • 2015 - University of Queensland (Uniquest - AstraZeneca) - $76,020.00
      Funded ProjectRepurposing an Aurora B inhibitor and a myeloperoxidase inhibitor for serous ovarian cancer
    • 2015 - University of Queensland (UQ-Ochsner Seed Fund for Collaborative Research) - $22,500.00
      Funded ProjectThe role of cancer stem cells in colorectal cancer metastasis: Phase II – identifying therapeutic strategies
    • 2014 - Cancer Council Queensland (Project Grant) - $200,000.00
      Funded ProjectMacrophages facilitate prostate cancer bone metastasis
    • 2014 - Cancer Council Queensland (Project Grant) - $200,000.00
      Funded ProjectTargeting CDCP1 to reduce tumour burden and ascites in clear cell ovarian cancer
    • 2014 - Cancer Council Qld (Project Grant) - $0.00
      Funded ProjectTargeting CDCP1 to reduce tumour burden and ascites in clear cell ovarian cancer
    • 2014 - Cancel Council Qld (Project Grant) - $0.00
      Funded ProjectMacrophages facilitate prostate cancer bone metastasis
    • 2013 - ARC (Equipment Grant) - $0.00
      Funded ProjectMicro-ultrasound plus LAZR Photoacoustic Imaging Platform
    • 2013 - National Health and Medical Research Council (Project Grant) - $430,504.50
      Funded ProjectCharacterisation of novel hormone receptors
    • 2012 - Cancer Council Queensland (Project Grant) - $199,782.00
      Funded ProjectTargeting Inflammatory Pathways in Epithelial Ovarian Cancers
    • 2012 - Cancer Council Queensland (Project Grant) - $200,000.00
      Funded ProjectA novel Src regulated protease activated signalling pathway in hematogenous metastasis
    • 2012 - Cancer Council Qld (Project Grant) - $0.00
      Funded ProjectA novel Src regulated protease activated signalling pathway in hematogenous metastasis
    • 2012 - NHMRC (Project Grant) - $0.00
      Funded ProjectNovel reagents for treating iron disorders
    • 2011 - Australian Research Council (Future Fellowship) - $0.00
      Funded Project
    • 2011 - Cancer Council Qld (Project Grant) - $0.00
      Funded ProjectA novel molecular pathway in cancer
    • 2011 - Australian Research Council (Future Fellowship) - $822,856.00
      Funded ProjectA new Src, PKCdelta and Akt regulated protease activated receptor system in metastasis
    • 2011 - Cancer Council Queensland (Project Grant) - $200,000.00
      Funded ProjectA novel molecular pathway in cancer
    • 2010 - Wesley Research Institute (Project Grant) - $0.00
      Funded ProjectGenetic analysis of colorectal tumour initiating cells
    • 2010 - Prostate Cancer Foundation of Australia (Project Grant) - $0.00
      Funded ProjectNext generation DNA sequence analysis of prostate tumour initiating cells
    • 2009 - NHMRC (Project Grant) - $0.00
      Funded ProjectA novel receptor activated pathway in prostate cancer
    • 2009 - NHMRC (Project Grant) - $0.00
      Funded ProjectThe role of matriptase-2 and hemojuvelin in iron metabolism
    • 2009 - ARC (Equipment Grant) - $0.00
      Funded ProjectComprehensive cell imaging facility
    • 2004 - NHMRC (RD Wright Fellowship Career Development Award ) - $0.00
      Funded Project
    • 2000 - NHMRC (CJ Martin/RG Menzies Fellowship ) - $0.00
      Funded Project

    Awards

    • Sr Regis Mary Dunne Medal for outstanding research contribution
      Awarding Body: Mater Medical Research Institute
      Year awarded: 2011

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