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Bone marrow tissue resident macrophages are specialised immune cells that support haematopoietic stem cells (HSC) within the bone marrow and play a critical role in promoting the success of bone marrow transplantation. These macrophages are long-lived and resilient to myeloablative pre-conditioning used to eliminate the recipient’s HSC prior to delivery of the donor cell graft. These resilient, recipient-derived macrophages contribute to reconstitution of the haematopoietic niche and transplant success. RNASeq profiling has been used to identify a macrophage gene/protein that is upregulated in response to bone marrow injury (myeloablative pre-conditioning). Knockout mouse models are being used to determine whether this candidate protein is involved in post-transplant bone marrow recovery. This project will examine the frequency and phenotype of recipient-derived macrophages in post-transplant bone marrow.
4 weeks during the UQ Winter Research Program (29th June – 24th July 2026)
Hours of engagement must be between 20-36 hrs per week during the official program dates only.
Applicant will be based in the Bones and Immunology Research group at Mater Research, at the Translational Research Institute, Woolloongabba, Brisbane.
Please note this Enquiry Form is not an official application for the UQ Winter Program. Official applications need to be lodged via the UQ StudentHub from 23rd March 2026.
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The Role of a Macrophage Protein in Restoring Bone Marrow After Stem Cell Transplant
UQ Winter Research Program 2026Bone marrow tissue resident macrophages are specialised immune cells that support haematopoietic stem cells (HSC) within the bone marrow and play a critical role in promoting the success of bone marrow transplantation. These macrophages are long-lived and resilient to myeloablative pre-conditioning used to eliminate the recipient’s HSC prior to delivery of the donor cell graft. These resilient, recipient-derived macrophages contribute to reconstitution of the haematopoietic niche and transplant success. RNASeq profiling has been used to identify a macrophage gene/protein that is upregulated in response to bone marrow injury (myeloablative pre-conditioning). Knockout mouse models are being used to determine whether this candidate protein is involved in post-transplant bone marrow recovery. This project will examine the frequency and phenotype of recipient-derived macrophages in post-transplant bone marrow.
4 weeks during the UQ Winter Research Program (29th June – 24th July 2026)
Hours of engagement must be between 20-36 hrs per week during the official program dates only.
Applicant will be based in the Bones and Immunology Research group at Mater Research, at the Translational Research Institute, Woolloongabba, Brisbane.
Please note this Enquiry Form is not an official application for the UQ Winter Program. Official applications need to be lodged via the UQ StudentHub from 23rd March 2026.
Positions available for
UQ Enrolled Students
Contact Person Dr Susan Millard
Contact Email susan.millard@mater.uq.edu.au