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Pioneering CAR-T Therapy for Metastatic Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is a highly aggressive and treatment-resistant subtype of breast cancer with limited targeted therapy options. This project explores a first-in-class CAR-T cell therapy targeting a protein overexpressed in TNBC but minimally expressed in healthy tissues. The project will involve preclinical validation of this therapy in cancer cell lines and patient-derived models, with the potential to combine CAR-T cells with immune checkpoint inhibitors to enhance efficacy. This research contributes to the development of personalised and durable immunotherapy strategies for hard-to-treat cancers.