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Pancreatic cancer (PC) is a highly lethal malignancy characterized by exceptionally low survival rates and profound therapeutic resistance. While traditionally attributed to DNA mutagenesis, emerging evidence highlights the critical role of epigenetic dysregulation—particularly aberrant DNA methylation—as a driving force in PC initiation and progression.
This project focuses on a specialized subset of genes known as imprinted genes. Unlike conventional genes that are expressed simultaneously from both parental alleles, imprinted genes exhibit mono-allelic expression, with the inactive allele typically silenced via methylation. Given their vital role in regulating cellular growth and tissue development, this research seeks to determine how the loss of imprinting (LoI) drives tumorigenesis. This is a lab-based project.
Supervisors: Dr Michaela Kindlova and Assoc. Prof. Adam Ewing
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The role of imprinting in the pancreatic cancer initiation
Translational Bioinformatics group is located at Translational Research Institute, Lv4 Mater Research. Our team is focused on deciphering the relationship of disorders to genomic, transcriptomic, and epigenomics variation. Our studies often involve the creation of analytical pipelines that comprehensively characterise some aspect of the genome, transcriptome, and methylome/ imprintome, while generating data which are subsequently used for creating our own bioinformatics tools.Pancreatic cancer (PC) is a highly lethal malignancy characterized by exceptionally low survival rates and profound therapeutic resistance. While traditionally attributed to DNA mutagenesis, emerging evidence highlights the critical role of epigenetic dysregulation—particularly aberrant DNA methylation—as a driving force in PC initiation and progression.
This project focuses on a specialized subset of genes known as imprinted genes. Unlike conventional genes that are expressed simultaneously from both parental alleles, imprinted genes exhibit mono-allelic expression, with the inactive allele typically silenced via methylation. Given their vital role in regulating cellular growth and tissue development, this research seeks to determine how the loss of imprinting (LoI) drives tumorigenesis. This is a lab-based project.
Supervisors: Dr Michaela Kindlova and Assoc. Prof. Adam Ewing
Positions available for
Honours
Contact Person Dr Michaela Kindlova
Contact Email m.kindlova@mater.uq.edu.au